CONTENTS
Chapter l Introduction 1
Chapter 2 Pharmacokinetics and Pharmacodynamics: Rational Dosing and the Time Course of Drug Action 2
Chapter 3 Drug Receptors and Pharmacodynamics 17
Chapter 4 Drug Biotransformation 41
Chapter 5 Development and Regulation of Drugs 48
SECTIONⅡ AUTONOMIC DRUGS
Chapter 6 Introduction to Autonomic Pharmacology 59
Chapter 7 Cholinoceptor-Activating Drugs and Cholinesterase-Inhibiting Drugs 67
Chapter 8 Cholinoceptor-Blocking Drugs 74
Chapter 9 Adrenoceptor Agonists and Sympathomimetic Drugs 80
Chapter 10 Adrenoceptor Antagonist Drugs 95
SECTION Ⅲ DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM
Chapter 11 Introduction to the Pharmacology of CNS Drugs 104
Chapter 12 Sedative-Hypnotic Drugs 119
Chapter 13 The Alcohols 135
Chapter 14 Antiseizure Drugs 141
Chapter 15 General Anesthetics 148
Chapter 16 Local Anesthetics 155
Chapter 17 Skeletal Muscle Relaxants 164
Chapter 18 Pharmacologic Magnagement of Parkinsonisn and Other Movement Disorders 180
Chapter 19 Antipsychotic Agents and Lithium 187
Chapter 20 Antidepressant Agents 195
Chapter 21 Opioid Analgesics and Antagonists 205
Chapter 22 Drugs of Abuse 218
SECTION Ⅳ CARDIOVASCULAR-RENAL DRUGS
Chapter 23 Antihypertensive Agents 223
Chapter 24 Vasodilators and the Treatment of Angina Pectoris 231
Chapter 25 Drugs Used in Heart Failure 248
Chapter 26 Agents Used in Cardiac Arrhythmias 262
Chapter 27 Diuretis 276
SECTIONⅤ DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE
Chapter 28 Vasoactive Peptides 294
Chapter 29 The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Related Compounds 301
Chapter 30 Nitric Oxide 318
Chapter 31 Drugs Used in Asthma 325
SECTION Ⅵ ENDOCRINE DRUGS
Chapter 32 Hypothalamic and Pituitary Hormones 332
Chapter 33 Thyroid and Antithyroid Drugs 347
Chapter 34 Adrenocorticosteroids and Adrenocortical Antagonists 358
Chapter 35 The Gonadal Hormones and Inhibitors 374
Chapter 36 Pancreatic Hormones and Antidiabetic Drugs 400
Chapter 37 Agents That Affect Bone Mineral Homeostasis 407
SECTION Ⅶ AUTOCOIDS AND ANTI-AUTOCOID DRUGS
Chapter 38 Histamine, Serotonin, and the Ergot Alkaloids 413
SECTION Ⅷ DRUGS USED TO TREAT DISEASES OF THE BLOOD, IN-FLAMMATION, AND GOUT
Chapter 39 Agents Used in Anemias; Hematopoietic Growth Factors 424
Chapter 40 Drugs Used in Disorders of Coagulation 434
Chapter 41 Agents Used in Dyslipidemia 443
Chapter 42 Nonsteroidal Anti-Inflammatory Drugs, Nonopioid Analgesics, Anti-Rheumatic
Drugs, and Drugs Used in Gout 448
SECTION Ⅸ DRUGS THAT ACT IN THE IMMUNE SYSTEM
Chapter 43 Immunopharmacology 456
SECTION Ⅹ CHEMOTHERAPEUTIC DRUGS
Chapter 44 β-Lactam and Other Inhibitors of Cell Wall Synthesis 464
Chapter 45 Tetracyclines, Macrolides, Clindamycin Streptogramins, and Chloramphenicol 477
Chapter 46 Aminoglycosides and Spectinomycin 486
Chapter 47 Sulfonamides, Trimethoprim, and Quinolones 492
Chapter 48 Antimycobacterial Drugs 497
Chapter 49 Antifungal Agents 505
Chapter 50 Antiviral Agents 511
Chapter 51 Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, and Sterilants 516
Chapter 52 Clinical Use of Antimicrobial Agents 522
Chapter 53 Antiprotozoal Drugs 529
Chapter 54 Clinical Pharmacology of the Antihelminthic Drugs 553
Chapter 55 Cancer Chemotherapy 561
SECTION Ⅺ TOXICOLOGY
Chapter 56 Introduction to Toxicology: Occupational and Environmental 569
Chapter 57 Heavy Metal Intoxication and Chelators 574
Chapter 58 Management of the Poisoned Patient 585
SECTION Ⅻ SPECIAL TOPICS
Chapter 59 Special Aspects of Perinatal and Pediatric Pharmacology 590
Chapter 60 Special Aspects of Geriatric Pharmacology 595
Chapter 61 Dermatologic Pharmacology 598
Chapter 62 Drugs Used in the Treatment of Gastrointestinal Diseases 616
Chapter 63 Therapeutic and Toxic Potential of Over-the-Counter Agents 622
Chapter 64 Dietary Supplements and Herbal Medications 634
Chapter 65 Rational Prescribing and Prescription Writing 644
Chapter 66 Important Drug Interactions and Their Mechanisms 648
English-Chinese Indexes 661